vacuolation , auch: vacuolization

P. tropiduri has more variability in shape and greater vacuolation of the gametocytes.

Vacuolation is most obvious in neurons and epithelial cells.

This autodigestion is responsible for the cytoplasmic vacuolation.

Histological signs of vacuolation provide a differential diagnosis.

This method is a cheap and easy way to study lysosomal vacuolation, autophagy, and apoptosis.

The senescent heterocyst undergoes vacuolation and finally breaks off from the filament causing fragmentation.

Consistent with this possibility, previous work suggested that mitochondrial vacuolation was developed from expansion of the intermembrane space [ 17 ] .

However, the possibility that the vacuoles represent autophagic vacuolation has not been ruled out, because the source of the vacuolar membrane was not known.

This showed loss of smooth muscle fibres, with remaining fibres showing hypertrophy, vacuolation, or degenerative features (Fig 2).

This precedes the peak of mitochondrial vacuolation and the onset of the disease by two to three months [ 15 ] .

Mitochondrial vacuolation was also reported in another transgenic line SOD1 G37R [ 7 ] .

The mitochondrial vacuolation could in part be the result of persistent mitochondrial dysfunction and further facilitate the downstream motor neuron degeneration events.

The distension of the rough endoplasmic reticulum and the cell vacuolation caused by the antagonist probably reflect a direct effect on pancreatic acinar cells.

The submucosal and myenteric neural plexuses seemed normal in number and morphology with no intraneuronal inclusions or vacuolation present.

X-linked myopathy with excessive autophagy is a rare childhood onset disease characterized by progressive vacuolation and atrophy of skeletal muscle.

However, some mutant SOD1 causes motor neuron degeneration without mitochondrial vacuolation [ 8 11 36 ] .

This results in abnormal accumulation of the molecules normally processed by the enzyme, and this accumulation leads to vacuolation of most tissues.

Because the outer mitochondrial membrane normally tightly wraps around mitochondria, the extension of the outer membrane during vacuolation requires new membranes.

It is possible that mitochondrial vacuolation represents an accelerated form of mitochondrial damage caused by high levels of mutant SOD1 accumulation.

In the rat hormonal changes were accompanied by the histological observation of vacuolation (empty cavities) of the cells of the adrenal cortex.

The likelihood is that the changes on magnetic resonance imaging are a marker of abnormalities in myelin (such as vacuolation, expanded extracellular spaces, oedema, or demyelination).

However, in a freshly prepared blood smear, the presence of vacuolation in addition to toxic neutrophils, reflects endotoxemia resulting in autolysis of neutrophils.

These are diffuse loss of visceral epithelial cells (podocyte) foot processes, vacuolation, and growth of microvilli on the visceral epithelial cells.

These observations indicate that neither MPT (expansion of matrix) nor autophagy (in which lysosomes participate) is responsible for mutant SOD1-induced mitochondrial vacuolation.

This disease can only be confirmed at the post-mortem, which includes identification of bilaterally symmetrical vacuolation of the neuropil and vacuolation in neurones.