uterotonic

It is safe in normal food quantities, but large amounts can have uterotonic effects.

If further uterine stimulation is needed, treatment with other forms of oxytocic uterotonic drugs should be used.

A uterotonic is an agent used to induce contraction or greater tonicity of the uterus.

Carbetocin works as an oxytocic, antihemorrhagic and uterotonic drug in the peripheral nervous system.

Other effects are: analgesic, uterotonic, decongestive and anti-inflammatory.

Uterotonic effect of Evodia rutaecarpa alkaloids.

Consequently, the administration of carbetocin or another oxytocin analog during or immediately following birth will have increased uterotonic and contractile effect.

This improved ergobasine has found worldwide application as a dependable uterotonic, hemostatic remedy under the trade name Methergine, and is today the leading medicament for this indication in obstetrics.

Early pharmacological testing by Sandoz in laboratory animals showed that LSD can stimulate uterine contractions, with efficacy comparable to ergobasine, the active uterotonic component of the ergot fungus.

Cyclotides have been reported to have a wide range of biological activities, including anti-HIV, insecticidal, anti-tumour, antifouling, anti-microbial, hemolytic, neurotensin antagonism, trypsin inhibition, and uterotonic activities.

Then came a major development, both for chemistry and for medicine: the isolation of the specifically uterotonic, hemostatic principle of ergot, which was published simultaneously and quite independently by four institutions, including the Sandoz laboratories.

I further employed my synthetic procedure to produce new lysergic acid compounds for which uterotonic activity was not prominent, but from which, on the basis of their chemical structure, other types of interesting pharmacological properties could be expected.

Although in vivo studies in rats confirmed the uterotonic activity of the purified peptide, it was another 20 years before the cyclic cystine knot motif and structure of the purified peptide were elucidated.

Nevertheless, the pharmacologist H. H. Dale discovered that ergotoxine, besides the uterotonic effect, also had an antagonistic activity on adrenaline in the autonomic nervous system that could lead to the therapeutic use of ergot alkaloids.

A Cochrane review suggests that active management (use of uterotonic drugs, cord clamping and controlled cord traction) of the third stage of labour significantly reduces severe maternal bleeding and anemia compared to expectant management.

This was not only of scientific interest, as confirmation of the chemical structure of ergobasine, but also of practical significance, because ergobasine, the specifically uterotonic, hemostatic principle, is present in ergot only in very trifling quantities.

Most violas (all tested) and many plants of the Violaceae plant family contain cyclotides, which have a diverse range of in vitro biological activities when isolated from the plant, including uterotonic, anti-HIV, antimicrobial, and insecticidal activities.

Active management is described as the administration of a uterotonic drug within one minute of fetal delivery, controlled traction of the umbilical cord and fundal massage after delivery of the placenta, and performance of uterine massage every 15 minutes for two hours afterward.