ulcerogenic

No patient had a history of taking ulcerogenic drugs, such as aspirin, indomethacin, and steroids.

Unlike other NSAIDs, it does not inhibit cyclooxygenase or lipooxygenase, and is not ulcerogenic.

The compound is many times more potent than acetylsalicylic acid and clinically generally resembles ibuprofen and indoprofen in its pharmacological effects, but with significantly less ulcerogenic activity.

Thus, continuous generation of PGE by gastric mucosa is crucial for the maintenance of mucosal integrity and protection against ulcerogenic and necrotizing agents.

It has been shown that oral administration of lipid mixtures containing surface-active phospholipids provides significant protection to the gastric mucosa against a variety of ulcerogenic agents, including acid.

Subsequently he and others have shown a mix of phospholipids and phytosterol in these diets will prevent ulcers where rats are exposed to ulcerogenic treatment with NSAIDs.

The combination of phospholipids and phytosterols may be of value in the prevention and treatment of duodenal ulceration and protection against the ulcerogenic effect of NSAIDs.

Before the confirmed existence of COX-2, the Dupont company had developed a compound, DuP-697, that was potent in many anti-inflammatory assays but did not have the ulcerogenic effects of NSAIDs.

Wallace JL, Reuter BK, Cicala C, McKnight W, Grisham MB, Cirino G. Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat.

However, the systemic use of NSAID's are associated with several side-effects, namely cardiovascular thrombotic events, such as myocardial infarction and stroke, gastric irritability or ulcerogenic effects, blood dyscrasias, and nephrotoxicity; among these gastric irritability is most common.