tumour suppressor gene

Work on these tumour suppressor genes has become a worldwide industry.

Tumour suppressor genes seem to be very important in colorectal carcinogenesis.

It can behave as a tumour suppressor gene.

We might be able to design other viruses that deliver tumour suppressor genes to prevent cancer.'

Since then much evidence has accrued that p53 is a tumour suppressor gene involved in a wide range of human malignancies.

These genes are now known as tumour suppressor genes and work on them has become a world-wide industry.

He proposed the existence of cell cycle check points, tumour suppressor genes and oncogenes.

Several drug therapies are being developed based on p53, the tumour suppressor gene that protects the cell in response to damage and stress.

Its expression is down-regulated in mammary tumours, it may function as a tumour suppressor gene.

There were oncogenes and there were tumour suppressor genes.

Numerically a much smaller group, tumour suppressor genes inhibit cell proliferation and tumorigenicity.

The first direct evidence for DCC as a tumour suppressor gene was published in 1995.

Consequently, unlike other tumour suppressor genes, only one allele need be mutated to produce a phenotypic effect.

This model applies to many conditions involving tumour suppressor genes such as TSC.

TIG1 may be a tumour suppressor gene whose diminished expression is involved in the malignant progression of prostate cancer.

Various mutations in both oncogenes and tumour suppressor genes have been implicated heavily in the development of cancer.

The presence of other chromosomal deletions in colorectal cancer suggests that several more tumour suppressor genes have yet to be identified.

APC is a tumour suppressor gene, acting as a "gatekeeper" to prevent development of tumours.

Perhaps the most exciting of future possibilities for genetic intervention in cancer is the direct manipulation of oncogenes or tumour suppressor genes.

Enough premalignant cells are present in the bulk of stool to permit the analysis of tumour suppressor gene mutations by this technique.

The impending characterisation of a melanoma related tumour suppressor gene from human chromosome 9 should make this type of approach even more useful.

DCC (deleted in colorectal cancer) is a candidate tumour suppressor gene located on chromosome 18.

The discovery of oncogenes and tumour suppressor genes has opened new avenues for exploring the control of cellular growth in health and disease.

Nasopharyngeal carcinoma-associated gene 6 (NGX6) acts as a tumour suppressor gene in colon cancer.

A further mutation may cause loss of a tumour suppressor gene, disrupting the apoptosis signalling pathway and resulting in the cell becoming immortal.