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Trophic hormones from the anterior pituitary include:
The trophic hormones increase CYP11A1 gene expression through transcription factors such as steroidogenic factor 1 (SF-1), by the α isoform of activating protein 2 (AP-2) in the human, and many others.
However, Na + /H + activity is enhanced in several models of increased gastrointestinal cell proliferation, including the neonatal liver, the pancreas after exposure to trophic hormones, and the intestine after partial resection or exposure to the carcinogen 1,2 dimethylhydrazine.