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Thus a lesion of the trochlear nucleus affects the contralateral eye.
Central damage is a damage to the trochlear nucleus.
The trochlear nucleus is unique in that its axons run dorsally and cross the midline before emerging from the brainstem.
An exception is the trochlear nucleus in the brainstem, which innervates the superior oblique muscle of the eye on the opposite side of the face.
The abducens nucleus is close to the midline, like the other motor nuclei that control eye movements (the oculomotor and trochlear nuclei).
A peripheral lesion is a damage to the bundle of nerves, in contrast to a central lesion, which is a damage to the trochlear nucleus.
The trochlear nucleus and its axons within the brainstem can be damaged by infarctions, hemorrhage, arteriovenous malformations, tumors and demyelination.
Oddly, fibers from the trochlear nucleus cross over in the midbrain at the superior medullary velum and exit posteriorly, (this is the only cranial nerve to do so).
The oculomotor nucleus and nerve (cranial nerve III) and the muscles it serves or the trochlear nucleus and nerve (cranial nerve IV) and the muscles it serves are affected.
Noradrenergic cell group Acg is a group of cells fluorescent for norepinephrine that are located in the central gray of the midbrain at the level of the trochlear nucleus in the squirrel monkey (Saimiri) and to a lesser degree in the macaque.