transcortin

In addition, approximately 4% of serum testosterone is bound to transcortin.

Therefore, plasma transcortin levels increase during pregnancy, and are decreased in cirrhosis.

A similarly small fraction of serum estradiol is bound to transcortin as well.

Cortisol is thought to be biologically active only when it is not bound to transcortin.

Corticosterone - About 78% of serum corticosterone is bound to transcortin.

Cortisol - Approximately 75% of the cortisol in circulation is bound to transcortin.

Other steroid hormones such as progesterone, cortisol, and other corticosteroids are bound by transcortin.

Examples include albumin, transferrin, transthyretin, retinol-binding protein, antithrombin, transcortin.

It decreases with high levels of insulin, growth hormone, insulin-like growth factor 1 (IGF-1), androgens, prolactin and transcortin.

Endogenous glucocorticoids and some synthetic corticoids have high affinity to the protein transcortin (also called corticosteroid-binding globulin), whereas all of them bind albumin.

Aldosterone - Approximately 17% of serum aldosterone is bound to transcortin, while another 47% is bound to serum albumin.

Testosterone and estradiol circulate in the bloodstream, bound mostly to SHBG and to a lesser extent serum albumin and corticosteroid-binding globulin (CBG) (AKA transcortin).

Training caused no change in total testosterone, but there were decreases in free testosterone, progesterone, androstendione, DHEA, cortisol, transcortin, and in the cortisol:CBG ratio, suggesting androgen turnover increased with training intensity, without change in total testosterone.