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Your doctor or pharmacist can provide more information about topotecan.
This list is not complete and other drugs may interact with topotecan.
Take the topotecan capsule with a full glass (8 ounces) of water.
Store topotecan capsules in the refrigerator and protect them from light.
Do not use topotecan if you are pregnant.
If you vomit after taking a topotecan capsule, do not take another dose that same day.
Call your doctor for instructions if you miss any of your topotecan doses.
But the topotecan patients experienced slightly more severe side effects, particularly a drop in their immune system's ability to fight infections.
You should not breast-feed while you are using topotecan.
To make sure you can safely use topotecan, tell your doctor if you have any of these other conditions:
The use of topotecan has been investigated.
It is water-soluble and more potent than topotecan.
You should not use topotecan if you have:
It is not known whether topotecan passes into breast milk or if it could harm a nursing baby.
Some type I topoisomerase inhibitors include camptothecins: irinotecan and topotecan.
Type 1 topoisomerase is inhibited by irinotecan, topotecan and camptothecin.
Topotecan worked on the paternal chromosome, dampening antisense transcription there.
Do not receive a "live" vaccine while using topotecan, and avoid coming into contact with anyone who has recently received a live vaccine.
Hycamtin or topotecan is a semi-synthetic derivative of camptothecin.
Do not crush or break a topotecan capsule, or use a capsule that has been accidentally broken.
They chose one, topotecan, and tested it to see whether it could do the same thing in vivo in a mouse.
Chemotherapy with topotecan and cyclophosphamide is frequently used in refractory setting and after relapse.
However, patients who received topotecan and cyclophosphamide fared no better than those treated with VAC alone.
They administered topotecan directly into the brain and later into spinal fluid; in both cases it was able to activate paternal Ube3a.
Combinations with carboplatin, gemcitabine, paclitaxel, vinorelbine, topotecan, and irinotecan are also used.