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This gene belongs to the tissue inhibitor of metalloproteinases gene family.
The most notorious endogenous metalloproteinases are tissue inhibitors of metalloproteinases (TIMPs).
This determines substrate specificity and is the site for interaction with TIMP's (tissue inhibitor of metalloproteinases).
Balance in the MMP activity is usually achieved by tissue inhibitor of metalloproteinases (TIMP).
TIMP metallopeptidase inhibitor 2, a tissue inhibitor of metalloproteinases, also known as TIMP2, is a human gene, thought to be a metastasis suppressor.
SST was found to increase matrix metalloproteinases activity with reduced tissue inhibitors of metalloproteinases activities on hepatic stellate cells possibly via P38 pathway (Sakaida et al., 2004).
TIMP metallopeptidase inhibitor 1, also known as TIMP1, a tissue inhibitor of metalloproteinases, is a glycoprotein that is expressed from the several tissues of organisms.
A further degree of regulation of MMP activity is afforded by the family of inhibitors: tissue inhibitors of metalloproteinases (TIMPs) [ 28].
The hemopexin-like domain has been shown to play a functional role in substrate binding and/or in interactions with the tissue inhibitors of metalloproteinases (TIMPs), a family of specific MMP protein inhibitors.
The matrix metalloproteinases are inhibited by specific endogenous tissue inhibitors of metalloproteinases (TIMPs), which comprise a family of four protease inhibitors: TIMP1, TIMP2, TIMP3 and TIMP4.
From 1996 through 1997, she received the Association of Professors of Obstetrics and Gynaecology (APOG)-Serono Research Grant for her study "Implantation in Pre-Eclampsia: The Expression of Gelatinases and Tissue Inhibitors of Metalloproteinases in Human Placentas."