therapeutic index

A quantitative measure of this fact is called the therapeutic index.

Medication is said to have a narrow or wide therapeutic index.

In addition, the therapeutic index of dextroproxyphene is relatively small.

Tobramycin is thus said to be a drug with a narrow therapeutic index.

It also showed a higher therapeutic index, yet the cardiotoxicity remained.

Patients treated often suffered side effects due to the narrow therapeutic index of these products.

A low therapeutic index indicates that there is a high risk of toxicity when using the drug.

The result showed a favorable safety profile for the drug with a therapeutic index in rats greater than 250.

However this use has been limited due to their narrow therapeutic index, and the development of more-advanced medicines for these conditions.

While the amount of the overdose was not cited, the therapeutic index for chloroquine is known to be small.

Severe toxicity was less common in our study, however, and the three-drug combination seems to have a better therapeutic index.

The therapeutic index (ratio of effectiveness to toxicity) for bromide is small.

They would have a high therapeutic index, that is, phage therapy would be expected to give rise to few side effects.

Fentanyl has a therapeutic index of 270.

The therapeutic index in mice was also established:

Colchicine has a relatively low therapeutic index.

For instance most formularies will not cover barbiturates since their therapeutic index is low compared to benzodiazepines.

This gives the compound a very small therapeutic index and it is very unlikely to ever appear on the medicinal market.

The therapeutic index of cardiac glycosides, like cerberin, is about a ratio of 2:1.

Due to its very narrow therapeutic index, Theophylline is known to cause a wide variety of side-effects and even toxicity.

Even less-safe are drugs such as digoxin, a cardiac glycoside; its therapeutic index is approximately 2:1.

Benzodiazepines have a wide therapeutic index and taken alone in overdose rarely cause severe complications or fatalities.

Nevertheless, the therapeutic index can be viewed as an upper bound to the protective index for a given substance.

Narrow therapeutic index : Where the difference between the effective dose and the toxic dose is small.

Etretinate has a low therapeutic index and a long elimination half-life (t) of 120 days, which make dosing difficult.