tetramethylammonium iodide

Tetramethylammonium iodide in trifluoromethanesulfonic acid is an effective reagent for selective debromination of bromophenols at the ortho and para positions.

Metabolism/Excretion: Parenteral administration of radio-labeled tetramethylammonium iodide to rats resulted in almost the whole dose being excreted in urine, without any evidence of metabolic transformation.

It must exist in association with a counter-ion, and is most commonly found in simple salts such as tetramethylammonium chloride, tetramethylammonium bromide, tetramethylammonium iodide and tetramethylammonium hydroxide.

Distribution: Intraperitoneal administration of radio-labeled tetramethylammonium iodide to mice showed that TMA was rapidly distributed to all parts of the body, with the highest concentrations being in the kidney and liver.