sulfonylureas

"Everybody knows that sulfonylureas are kind of a losing game," he said.

It has more side effects than other sulfonylureas and its use is no longer recommended.

If you take sulfonylureas, you may be at higher risk for low blood sugar.

A 2012 study found sulfonylureas raise the risk of death compared with metformin.

They act on the same potassium channels as sulfonylureas, but at a different binding site.

Side effects are uncommon when sulfonylureas are taken as prescribed.

Sulfonylureas are used primarily for the treatment of diabetes mellitus type 2.

Remarkably, this type of diabetes often responds well to sulfonylureas and insulin may not be necessary.

Sulfonylureas are effective in the K channel forms of neonatal-onset diabetes.

After metformin, sulfonylureas are a common second choice among oral drugs to treat type 2 diabetes.

Sulfonylureas have been around since the mid-1950s, making them the first type of oral drug ever used to treat patients with type 2 diabetes.

In about 10% of patients, sulfonylureas alone are ineffective in controlling blood glucose levels.

This type of diabetes can often be treated with sulfonylureas with excellent results for decades.

Newer "second generation" sulfonylureas have fewer side effects and are often used in combination with metformin.

Sulfonylureas are used almost exclusively in diabetes mellitus type 2 .

Many of these patients were treated with sulfonylureas with varying degrees of success.

Plasma half life is 36 hours; the drug is effective for about 24 hours, longer than other sulfonylureas.

Most sulfonylureas and aspirin can be detected on a blood or urine drug screen tests, but insulin cannot.

Sulfonylureas were the first widely used oral anti-hyperglycaemic medications.

Sulfonylureas can be used to treat neonatal diabetes.

In many cases, neonatal diabetes may be treated with oral sulfonylureas such as glyburide.

Blood sugar is more likely to go too low and cause hypoglycemia in people who take insulin or certain diabetes medications (such as sulfonylureas).

It is slightly less effective than metformin when used as a monotherapy and does not cause a weight gain compared to sulfonylureas.

Chlorpropamide and other sulfonylureas encourage weight gain, so they are generally not favored for use in very obese patients.

Sulfonylureas are potentially teratogenic and cannot be used in pregnancy or in patients who may become pregnant.