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Lacking sulpha drugs or penicillin, heat was the only defence against a bacterial infection.
As the compound readily form diazo compounds, it is used to make dyes and sulpha drugs.
The original antibacterial sulfonamides (sometimes called sulfa drugs or sulpha drugs) are synthetic antimicrobial agents that contain the sulfonamide group.
Sulfonamide or sulphonamide is the basis of several groups of drugs.
Before I left I took a half-pound packet of sulphonamide from the car boot.
Some veterinarians recommend measuring tear production prior to sulphonamide administration, and at various intervals after administration.
"I'll give him an injection and leave you some sulphonamide - that's what Mr Farnon uses in these cases."
Sulfonamide or sulphonamide may refer to:
M & B 693 was one of the first generation of sulphonamide antibiotics, It has been reported as the first chemical cure for pneumonia.
The discovery of the Sulphonamide drugs by Messrs May and Baker on their 693rd attempt revolutionised our records.
When sulphanilic acid is added (in the picture its sulphonamide is shown instead), the nitrites form a diazonium salt.
We have already seen that a sulphonamide acts as a false building block; it fits into the construction but is the wrong shape for farther blocks to be added.
'Indapamide' is a non-thiazide sulphonamide diuretic medication marketed by Servier, generally used in the treatment of hypertension, as well as decompensated cardiac failure.
Theoretically, the sulphonamide block could be by-passed if ready-made folic acid were available, but in practice microbes which make their own folic acid are unable to take it up from outside.
In particular, he was interested in the possibility that sulphaguanidine (or a related sulphonamide) might be a causal prophylactic against malaria, as they could be manufactured in Australia, unlike atebrin and plasmoquine.
We had just started our first lectures, when apart from helping to prepare the Sulphonamide paper I was given a weekend off to visit City Temple friends who had started a Community House at Highbury New Park.
He was saved by the new sulphonamide drug, Sulphapyridine, known at the time under the research code M&B 693, discovered and produced by May & Baker Ltd, Dagenham, Essex - a subsidiary of the French group Rhône-Poulenc.
During the last years of the war it was noticed that rather a high proportion of soldiers were failing to be cured by the standard doses of M & B 693, as the sulphonamide was called, and this was the first clue to the potential in the gonococcus for developing resistance to antibiotics.
If you are allergic to sulfa drugs, tell your doctor.
Some people don't respond well at all to sulfa drugs.
It was a time when doctors were first using sulfa drugs to cure pneumonia.
The aim of the new program will be to detect antibiotics and sulfa drugs.
By the 1940s, over 500 related sulfa drugs were produced.
He went on to develop a succession of life-saving sulfa drugs.
This is different from the common sulfa drugs allergy.
One had a sulfa drug that in allergic people could cause a fatal rash.
Alternative treatments for persons allergic to sulfa drugs have not yet been identified.
A hypo full of sulfa drugs doesn't have to be kept secret.
Without sulfa drugs or modern antibiotics, heat was the only defense against a bacterial infection.
We have sulfa drugs and you can load her up with Demerol."
Sulfa drugs, a type of antibiotic, have been found to cause cancer in mice and rats.
Sulfa drugs at the time could have saved lives but were not available in San Mango.
Penicillin and sulfa drugs proved highly successful in this regard.
At these very low levels many additional samples showed traces of sulfa drugs that could not be confirmed.
I always carried an anesthetic with me in those days before we had antibiotics or even sulfa drugs."
His scholarship wasn't good enough to make sulfa drugs or penicillin, but something simple like that would be no problem at all.
A sulfa drug allergic reaction can be fatal.
Sulfisoxazole is a sulfa drug that also fights bacteria in the body.
This discovery influenced the use of sulfa drugs.
He was sprinkling what Michael guessed was some kind of sulfa drug on the wound.
This was later followed by sulfonamides (sulfa drugs) and penicillin.
While in the service, Wallace nearly died of spinal meningitis, but prompt medical attention with sulfa drugs saved him.
The sulfa drug Sulfathiazole was one of the results of these research activities.
Do not take a sulfonamide without first talking to your doctor if you are breast-feeding a baby.
The discovery and development of this first sulfonamide drug opened a new era in medicine.
The infection was treated with sulfonamide and other drugs to determine their effectiveness.
The sulfonamide group forms a unique polar interaction with the enzyme.
The first type tested the efficacy of sulfonamide drugs.
A sulfonamide (compound) is a compound that contains this group.
A secondary amine in the same reaction will directly form an insoluble sulfonamide.
Before taking a sulfonamide, tell your doctor if you are taking any of the following medicines:
In a similar protocol, the levels of sulfonamide in blood can be detected similarly with the same principles.
The most common medications used to treat coccidian infections are in the sulfonamide family.
A tertiary amine will not react with the sulfonamide but is insoluble.
No responding on common antibiotics as sulfonamide and beta-lactams like penicillin.
The resulting sulfonamide structure is extremely stable.
The concurrent use of potentiated sulfonamide antibiotics is considered particularly dangerous.
Antibiotic therapy with a sulfonamide, most commonly trimethoprim-sulfamethoxazole, is the treatment of choice.
Approximately 3% of the general population have adverse reactions when treated with sulfonamide antimicrobials.
Chemically, it is a molecule containing the sulfonamide functional group attached to an aniline.
Stevens-Johnson syndrome (particularly when used with a sulfonamide)
Two regions of the sulfonamide antibiotic chemical structure are implicated in the hypersensitivity reactions associated with the class.
By the late 1930s, a number of ophthalmologists reported success in treating trachoma with sulfonamide antibiotics.
The invention and use of antibiotics, beginning with sulfonamide and penicillin, was another step in making elective surgery possible.
The ortho isomer is separated and converted to the sulfonamide with ammonia.
In contrast to other sulfonamide drugs, sultiame is devoid of antibacterial activity.
Though structurally distinct from dapsone, the sulfonamide group of antibacterial drugs also work in this way.
Hence the sulfonamide antibacterials exhibit a bacteriostatic rather than bactericidal effect.