The girl seemed likely to continue into adulthood with substantial social and emotional difficulties.
The company, which has had substantial financial difficulties, cut back marketing earlier this year.
It can be evaluated and, if necessary, removed from a vacant building without substantial difficulty.
One in five American children of all races, income levels and intelligence have substantial difficulty in learning to read.
Juggling is usually considered to be "technical" if the skills are of substantial difficulty.
Like many other clubs, it went through substantial financial difficulties in the late 1970s, and closed at the end of that decade.
Doing engineering there would present substantial difficulties, even if a collapsed star were handy.
This balancing question is resolved differently in different states, often with substantial difficulty.
Actually casting the two leads met with substantial difficulty.
So we are faced with a real, substantial difficulty to overcome.