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The substantia propria (or stroma of cornea) is fibrous, tough, unyielding, and perfectly transparent.
Once initiated, the disease normally develops by progressive dissolution of Bowman's layer, which lies between the corneal epithelium and Stroma of cornea.
Macular corneal dystrophy, also known as Fehr corneal dystrophy named for German ophthalmologist Oskar Fehr (1871-1959), is a rare pathological condition affecting the stroma of cornea.