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Beta-adrenergic receptors are coupled to the stimulatory G protein.
EP2 and EP4 receptors signal primarily through stimulatory G protein (Gs), increasing adenylyl cyclase (AC) activity and subsequent cAMP formation.
When the 5-HT receptor is activated by serotonin, it sets off a cascade of events starting with release of the stimulatory G protein G from the GPCR complex.
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