squid giant axon

He discovered the squid giant axon and the corresponding squid giant synapse.

The most successful and widely-used model of neurons, the Hodgkin-Huxley model, is based on data from the squid giant axon.

In 1937, John Zachary Young suggested that the squid giant axon could be used to study neuronal electrical properties.

The first kinesin was identified in squid giant axons as a protein involved in transport of vesicles [ 9, 10].

The squid giant axon, which is specialized to conduct signals very rapidly, is close to 1 millimetre in diameter, the size of a small pencil lead.

Bigfin reef squids are also valuable sources for squid giant axons used in research in neuroscience and physiology.

In fact, there are examples of neurons forming even tighter coupling: the squid giant axon arises from the fusion of multiple axons.

The voltage clamp is now a central piece of technology in modern neurophysiology, but was only possible to develop using the wide diameter of the squid giant axon.

During this time, Vale visited the Marine Biological Laboratory at Woods Hole so he could study this question in the squid giant axon.

One of the group of researchers who first explored the merits of the squid giant axon was John Zacharay Young, of University College, London.

August 28 - Alan Hodgkin and Andrew Huxley publish the Hodgkin-Huxley model of action potentials in neurons of the squid giant axon.

Much of what is known about axonal function comes from studying the squid giant axon, an ideal experimental preparation because of its relatively immense size (0.5–1 millimeters thick, several centimeters long).

In their Nobel Prize-winning work uncovering ionic mechanism of action potentials, Alan Hodgkin and Andrew Huxley performed experiments on the squid giant axon.

The Hodgkin-Huxley Model of an action potential in the squid giant axon has been the basis for much of the current understanding of the ionic bases of action potentials.

The squid giant axon is the very large (up to 1 mm in diameter; typically around 0.5 mm) axon that controls part of the water jet propulsion system in squid.

Alan Lloyd Hodgkin and Andrew Huxley described the model in 1952 to explain the ionic mechanisms underlying the initiation and propagation of action potentials in the squid giant axon.

Through use of voltage clamp techniques on a squid giant axon, they discovered that excitable tissues generally exhibit the phenomenon where a certain membrane potential must be reached in order to fire an action potential.

Young's work on squid giant axons was utilized by Andrew Huxley and Alan Hodgkin who in 1963 received the Nobel Prize for their work on the conduction of action potentials along nerve fibres.

The squid giant axon was the first preparation that could be used to voltage clamp a transmembrane current, and it was the basis of Hodgkin and Huxley's pioneering experiments on the properties of the action potential.

It is a set of nonlinear ordinary differential equations that were introduced by Alan Lloyd Hodgkin and Andrew Huxley in 1952 to explain the results of voltage clamp experiments on the squid giant axon.

The experiments started at the University of Cambridge, beginning in 1935 with frog sciatic nerve, and soon after they continued their work using squid giant axons at the Marine Biological Association Laboratory in Plymouth.

Alan Hodgkin and Andrew Huxley also employed the squid giant axon (1939) and by 1952 they had obtained a full quantitative description of the ionic basis of the action potential, leading the formulation of the Hodgkin-Huxley Model.

The advantages that this property conferred on Aplysia for those studying neurons is as great as that of the squid giant axon for the study of the action potential, and was early recognized by Arvanitaki, Tauc and their collaborators.

For example, action potentials move at roughly the same speed (25 m/s) in a myelinated frog axon and an unmyelinated squid giant axon, but the frog axon has a roughly 30-fold smaller diameter and 1000-fold smaller cross-sectional area.

The ionic basis of the action potential was elucidated in the squid giant axon in 1958 by Hodgkin and Huxley, developers of the original voltage clamp device and co-recipients of the 1963 Nobel Prize in Physiology or Medicine.