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Had Bassitt put in the cells on a charge of spreading depression.
Reading those pieces, he found that magnesium was often mentioned as preventing this spreading depression.
Further observations on the spreading depression of activity in the cerebral cortex.
The spreading depression wave progresses across the cortex at approximately 2 - 5 mm/minute.
This phenomenon, which in animal studies has been called "spreading depression," could help account for one spectacular aspect of migraines, the aura.
The theory of spreading depression as the source of migraine is predicated on data from one study, which has been impossible to duplicate.
In one instance, a reference to a neural phenomenon called "spreading depression" caused him to look for articles with that term in their titles.
Hyperthermic spreading depressions (SDs) were considered to have occurred when all of the following conditions were met: 1.
One popular theory in migraine pathophysiology is the depolarization theory, which centres around the phenomenon of cortical spreading depression.
Neuroscientists use the term cortical spreading depression to represent at least one of the following cortical processes:
Valproate and riboflavin were shown to have no effect on the triggering of cortical spreading depression though they are effective in migraine without aura.
"Cortical spreading depression causes and coincides with tissue hypoxia", Nat Neurosci.
Robert, along with collaborator Henry Tuckwell, formulated one of the first models of spreading depression using the continuum approach.
The paradoxical embolism then reaches the cortex, triggering cortical spreading depression, a phenomenon that leads to migraines.
The scintillating scotoma of migraine in humans may be related to the neurophysiologic phenomenon termed the spreading depression of Leão.
But clarification is needed on two issues, the theory of spreading depression and migraine, and the alleged effect of sumatriptan on the coronary arteries.
Somjem, G.G. Aristides Leão's discovery of cortical spreading depression.
Scintillating scotomas are most commonly caused by cortical spreading depression, a pattern of changes in the behavior of nerves in the brain during a migraine.
Cortical spreading depression is a wave of electrophysiological hyperactivity followed by a wave of inhibition, usually in the visual cortex.
On analysis by other investigators, spreading depression is probably due to false readings of scattered radiation (Olsen et al., Archives of Neurology, 1987, pages 156-61).
A study has shown that when the cortical spreading depression phenomenon was induced in mice, ANP was expressed in the brain.
Taken together, these results are compatible with a causal role of cortical spreading depression in migraine with aura, but not in migraine without aura.
Increased extracellular potassium ion concentration and excitatory glutamate contribute to the initiation and propagation of cortical spreading depression, which is the underlying cause of migraine aura.
"Cortical spreading depression (CSD): A neurophysiological correlate of migraine aura", Schmerz, May 17, 2008, Richter F, Lehmenkühler A.
"A delayed class of BOLD waveforms associated with spreading depression in the feline cerebral cortex can be detected and characterised using independent component analysis (ICA)", Magn Reson Imaging.