splenocyte

Dietary beta-carotene and astaxanthin but not canthaxanthin stimulate splenocyte function in mice.

Thus, even with substantial tumor burden, the combination of sub-lethal radiation and splenocyte transfer could stop tumor growth during the course of the study.

Because splenocyte transfer alone had resulted in no significant reduction in tumor burden, this group was not tested for survival benefit, for logistical reasons.

A splenocyte can be any one of the different white blood cell types as long as it is situated in the spleen or purified from splenic tissue.

In the group that received both radiation and splenocyte transfer, mice were irradiated at 600R one day prior to splenocyte transfer.

In agreement with previous observations, little infiltration was detected in Rip1-Tag2 mice receiving TCR splenocyte transfer (Figure 3).

Sub-lethal radiation increases lymphocyte infiltration of tumors Because the combination of sub-lethal radiation and TCR splenocyte transfer lead to significant reduction in tumor burden in both intervention and regression trials, we asked whether the radiation had increased the number of tumor-infiltrating lymphocytes.