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Portal hypertension may be important in determining the microcirculatory flow in the splenic pulp.
In this manner the vessels end, and the blood flowing through them finds its way into the interstices of the reticulated tissue of the splenic pulp.
There is congestion and dilatation of sinuses and scattered thrombosis, with focal necrosis in capillaries and splenic pulp.
The spleen therefore consists of a number of small spaces or areolae, formed by the trabeculae; in these areolae is contained the splenic pulp.
The arterioles end by opening freely into the splenic pulp; their walls become much attenuated, they lose their tubular character, and the endothelial cells become altered, presenting a branched appearance, and acquiring processes which are directly connected with the processes of the reticular cells of the pulp.