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The microbiological progression of the disease is similar to that of neurosyphilis, another spirochetal infection.
A Jarisch-Herxheimer reaction may occur after initial treatment of a spirochetal infection such as syphilis with a β-lactam antibiotic.
Survey of Birds and Lizards for Ixodid Ticks Acari and Spirochetal Infection in Northern California USA.
In the 1920s, French physicians Garin and Bujadoux described a patient with meningoencephalitis, painful sensory radiculitis, and erythema migrans following a tick bite, and they postulated the symptoms were due to a spirochetal infection.