slit diaphragm

The slit diaphragm is attached to the actin cytoskeleton of the cell.

The slit diaphragm is a part of the kidneys that regulates renal ultrafiltration.

In conjunction with the slit diaphragm, dendrin helps to prevent urinary protein loss.

Nephrin is a transmembrane protein that is a structural component of the slit diaphragm.

Blood is filtered through these slits, each known as a filtration slit or slit diaphragm.

In normal mature kidneys, dendrin is found only in the podocytes near the slit diaphragm.

CD2AP regulates the podocyte cytoskeleton and stabilizes the slit diaphragm.

Dendrin associates regularly with the slit diaphragm because the dendrin protein is located in these podocytes.

The space between adjacent podocyte foot processes is spanned by a slit diaphragm formed by several proteins including podocin and nephrin.

When there is glomerular injury in the kidneys, the dendrin protein relocates to the podocyte nucleus in the slit diaphragm.

NEPH1 and NEPH2 are involved in the blood filtration function of the kidney and are located in the slit diaphragm.

Proteins that are required for the correct function of the slit diaphragm include nephrin, NEPH1, NEPH2, podocin, and CD2AP.

Horseradish peroxidase readily diffuses from the capillaries through the mesangium, basement membrane, and slit diaphragms of the visceral epithelium into the urinary space, where it is transported to the tubule.

Within the brain, dendrin is normally found in the forebrain and hippocampus and in the kidneys, dendrin is normally found in the slit diaphragm and podocytes.

Nephrin is a zipper-like protein that forms the slit diaphragm, with spaces between the teeth of the zipper, big enough to allow sugar and water through, but too small to allow proteins through.

Exciting new work was presented on nephrin, the recently discovered slit diaphragm protein which seems to have a role in maintenance of the glomerular filtration barrier and may play an important role in the pathogenesis of proteinuria.

The slits are covered by slit diaphragms which are composed of a number of cell-surface proteins including nephrin, podocalyxin, and P-cadherin, which restrict the passage of large macromolecules such as serum albumin and gamma globulin and ensure that they remain in the bloodstream.