silibinin

In the biological literature, silybin is referred to as silibinin.

Silibinin and N-acetylcysteine appear to be the therapies with the most potential benefit.

Silibinin has been reported to exert a neuroprotective effect in mice.

Case control studies also suggest that silibinin reduces mortality from mushroom poisoning.

These studies have tested the ability of silymarin or silibinin to:

Except for mild gastroenteritis, intravenous silibinin monotherapy was well tolerated.

A long-term clinical trial of intravenous silibinin has began in the US in 2010.

Inhibitory effects of silibinin on cytochrome P-450 enzymes in human liver microsomes.

Silibinin is found in the roots of S. marianum while silyamandin can be found in the fruit.

There is also clinical evidence for the use of silibinin as a supportive element in alcoholic and Child grade 'A' liver cirrhosis.

When silybin [silibinin] was added to the penicillin treatment, survival was increased even more.

Subjects then began treatment with oral silibinin in combination with PEG-interferon and ribavirin for 12 weeks.

Both in vitro and animal research suggest that silibinin has hepatoprotective (antihepatotoxic) properties that protect liver cells against toxins.

Sonnenbichler J, Zetl I: [Mechanism of action of silibinin.

Silibinin inhibits adipocyte differentiation through a potential up-regulation of insig-1 and insig-2 at an early phase in adipocyte differentiation.

Some evidence indicates intravenous silibinin, an extract from the blessed milk thistle (Silybum marianum), may be beneficial in reducing the effects of death cap poisoning.

Laboratory experiments conducted using cancer cell lines have suggested that silibinin enhances the efficacy of cisplatin and doxorubicin against ovarian and breast cancer cells.

Lab experiments on mice showed that silibinin protects the hepatic cells against the toxin alpha-amanitin which causes Amanita phalloides mushroom poisoning.

Silibinin itself is mixture of two diastereomers silibinin A and silybinin B in approximately equimolar ratio.

An example of a hepatoprotective medicine is silibinin, derived from Milk Thistle, which selectively inhibits leukotriene formation by Kupffer cells.

Giving silibinin, a chemical found in milk thistle, intravenously (by IV) may lessen liver damage due to Amanita phalloides mushroom (death cap) poisoning.

Mira L, Silva M, Manso CF: Scavenging of reactive oxygen species by silibinin dihemisuccinate.

Gaedeke J, Fels LM, Bokemeyer C, et al.: Cisplatin nephrotoxicity and protection by silibinin.

Silibinin is used against poisoning by amanitas, such as the Death Cap (Amanita phalloides) as well as in cerebral edema and acute hepatitis therapy.

In a case series/phase I study, patients with HCV were treated with intravenous silibinin with and without PEG-interferon and ribavirin.