silent mutation

These individuals are often referred to as silent mutation carriers.

A silent mutation has no effect on the functioning of the protein.

Historically, silent mutations were thought to be of little to no significance.

Recent research suggests that silent mutations can have an effect on subsequent protein structure and activity.

Still, some believe that even silent mutations can cause significant behavioral phenotypes,and result in major phase changes.

Silent mutations: which code for the same (or a sufficiently similar) amino acid.

Mental disorders can be caused by silent mutations.

Silent mutations may also affect splicing, or transcriptional control.

Silent mutations have been employed as an experimental strategy and can have clinical implications.

Silent mutations can also be produced by insertions or deletions, which cause a shift in the reading frame.

Silent mutations affect protein folding and function.

Among three specimens of O. couesi, the sequence in this segment differed by only 1%, and all changes were silent mutations.

Conversely, silent mutations are mutations in which the amino acid sequence is not altered.

Although some minimal evolution would obviously have taken place in the meantime, this was essentially silent mutations and marginal adaptations to cooler habitat.

Because silent mutations do not alter protein function they are often treated as though they are evolutionarily neutral.

This can result in lower expression of a particular gene containing that silent mutation if the mutation occurs within an exon.

Silent mutations alter the secondary structure of mRNA.

Nucleotide mutations that do change the specified amino acid are usually harmful, and thus are less common than the silent mutations.

One silent mutation causes the dopamine receptor D2 gene to be less stable and degrade faster, underexpressing the gene.

On the rare occasions when these consequential mutations are beneficial, they are quickly favored by natural selection and outnumber the silent mutations.

This relied on the concept of silent mutations and the relative power of selection and drift in small populations [ 5, 6].

Second, "silent mutations" may alter the DNA sequence of a gene without altering the encoded amino acids.

Silent mutations can occur in non-coding regions (outside of genes within introns), or they may occur within exons.

Synonymous substitutions and mutations affecting noncoding DNA are collectively known as silent mutations.

The genetic differences among divergent populations can involve silent mutations (that have no effect on the phenotype) or give rise to significant morphological and/or physiological changes.