serotherapy

Bazy was a proponent of preventive serotherapy for treatment of tetanus.

Especially noteworthy is progress regarding the defensive reaction by which the blood may be rendered proof against their effect, by processes similar to vaccination-antipoisonous serotherapy.

Using the Federal Serotherapy Institute as technical-scientific base, he started a quick succession of memorable sanitation campaigns.

His name is associated with "Besredka's method", a type of vaccination he proposed for avoiding anaphylactic shock in the usage of serotherapy (sometimes referred to as "Besredka's desensitization").

Thus, on May 25, 1900, the Federal Serotherapy Institute destined to the production of sera and vaccines against the bubonic plague was created with the Baron Pedro Afonso as Director General and the young bacteriologist Oswaldo Cruz as Technical Director.

Nonetheless Roux is not convinced by this result since no one knows the collateral effects of the procedure and prefers to use serotherapy since more than one lab research- like the one accomplished by Charles Richet- demonstrated that the serum of an animal vaccinated against the disease includes the antibodies needed to defeat it.