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As for leukocytes during inflammation, cancer cells bound to E-selectin are released into the circulation unless secondary adhesion mechanisms are activated.
In T lymphocytes, engagement of the antigen receptor (TCR) by antigen leads to rapid but transient upregulation of LFA-1 affinity for ICAM-1 (ref.20) and this secondary adhesion event is one of the triggers for the lymphocyte-activation cascade.
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