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Individual sebaceous cells are large, with central dark nuclei and abundant foamy cytoplasm.
Recurring chalazia in the same area may sometimes be a symptom of sebaceous cell carcinoma, albeit rarely.
In other tissues linoleic acid is the target for delta 6 desaturase, but linoleic acid is degraded in sebaceous cells, allowing the enzyme to desaturate palmitic to sapienic acid.
The pathologist must be careful to differentiate such lesions from salivary neoplasms with sebaceous cells, such as sebaceous lymphadenoma and sebaceous adenoma, and their malignant counterparts sebaceous lymphadenocarcinoma and sebaceous carcinoma.