ribonucleotide reductase

It belongs to the family of drugs called ribonucleotide reductase inhibitors.

This conversion is catalysed by ribonucleotide reductase (see figure).

Unlike other glutaredoxins, glutaredoxin 2 (Grx2) cannot reduce ribonucleotide reductase.

Thioredoxins act as electron donors to peroxidases and ribonucleotide reductase.

The reduction of ribonucleotides to deoxyribonucleotides is catalyzed by ribonucleotide reductase.

This gene encodes one of two non-identical subunits for ribonucleotide reductase.

Simultaneously deoxyribosyl analogs are formed, via the enzyme ribonucleotide reductase.

Tezacitabine is a ribonucleotide reductase inhibitor.

Another target of gemcitabine is the enzyme ribonucleotide reductase (RNR).

Also, the interactions with the protomers resembles ribonucleotide reductase R2 protein dimer interaction, resembling a heart.

A hydrophilic core between four central helices (yellow ribbon) in the R2 subunit after the removal of iron from ribonucleotide reductase.

Nitric oxide induced cytostasis targets ribonucleotide reductase by rapid and reversible inhibition.

Glutaredoxins function as electron carriers in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase.

Triapine, a ribonucleotide reductase inhibitor, is being evaluated in clinical trials sponsored by the National Cancer Institute.

Human C6orf58 has been reported to interact with the enzyme ribonucleotide reductase as encoded by the vaccinia virus through a yeast two-hybrid screen.

The ribonucleotide reductase database (RNRdb)

Substrate binding to this site is thought to affect enzyme activity by altering the relative positions of the two subunits of ribonucleotide reductase.

Ribonucleotide reductase, a key enzyme in DNA synthesis, catalyses the de novo production of deoxyribonucleotide precursors.

The transferrin gallium complex inhibits the DNA synthesis by acting on the M2 subunit of the ribonucleotide reductase.

The iron-dependent enzyme, ribonucleotide reductase (RNR), is essential for DNA synthesis.

Motexafin gadolinium (proposed tradename Xcytrin) is an inhibitor of thioredoxin reductase and ribonucleotide reductase.

According to Hedley et al., gallium inhibits replicative DNA synthesis, the major gallium-specific target probably being ribonucleotide reductase.

The enzyme ribonucleotide reductase (RNR) catalyzes the de novo synthesis of dNTPs.

Other nucleoside analogs need to be triphosphorlated to give any antiviral effect, but ara-ADP inhibits the enzyme ribonucleotide reductase.

Hydroxyurea inhibits the rate-limiting enzyme supplying deoxyribonucleotides - ribonucleotide reductase - and substantially diminishes HIV replication.