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In the case of reparative dentin, other cells are needed to assume the role of the destroyed odontoblasts.
MTA provides a higher incidence and faster rate of reparative dentin formation without the pulpal inflammation.
Tertiary dentin, also known as reparative dentin, forms in reaction to stimuli, such as attrition or dental caries.
Growth factors, especially TGF-β, are thought to initiate the production of reparative dentin by fibroblasts and mesenchymal cells of the pulp.
Once reparative dentin forms, odontoblasts associated with the dentin change, and the pulpal fibroblasts lose p75 expression, which is a neurotrophin receptor.
The result showed that although glass ionomer cement caused a greater inflammatory response than Zinc-Oxide Eugenol cement, the inflammation resolved spontaneously with no increase in reparative dentin formation.