renal papillary necrosis

Any condition that involves ischemia can lead to renal papillary necrosis.

Ischemia that results may lead to renal papillary necrosis.

Bilateral hydronephrosis and renal papillary necrosis have also been reported in some cases.

Analgesic nephropathy is a cause of renal papillary necrosis.

Often, a patient with renal papillary necrosis will have numerous conditions acting synergistically to bring about the disease.

Renal papillary necrosis (tissue death)

Chronic use of phenacetin is known to lead to analgesic nephropathy characterized by renal papillary necrosis.

The combination of paracetamol with aspirin also creates the risk of renal papillary necrosis if large doses are taken chronically.

The specific kidney injuries induced by analgesics are renal papillary necrosis and chronic interstitial nephritis.

The damage is cumulative and most patients of renal papillary necrosis would have ingested at least 20 kg of analgesics in the past.

Damage to the renal papillae may result in death to cells in this region of the kidney, called renal papillary necrosis.

Renal papillary necrosis presents acutely with gross hematuria, flank pain, and tissue fragments in the urine.

Specifically, long term use of the analgesic phenacetin has been linked to renal papillary necrosis (necrotizing papillitis).

Inhibition of cyclooxygenases therefore rather selectively damages the renal papillae, increasing the risk of renal papillary necrosis.

They noted that chronic users of phenacetin had an increased risk of developing specific kidney injuries, namely renal papillary necrosis and chronic interstitial nephritis.

The most common toxic causes of renal papillary necrosis are NSAIDs, such as ibuprofen, acetylsalicylic acid, and phenylbutazone, in combination with dehydration.

Renal papillary necrosis is a form of nephropathy involving the necrosis of the renal papilla, which is supplied by the vasa recta.

Found in the renal pelvis, ureter, and capillaries supplying the nephrons, capillary sclerosis is thought to lead to renal papillary necrosis and, in turn, chronic interstitial nephritis.

High dose oral mesalazine does not seem to be nephrotoxic in rats when given for four weeks but both rats and dogs develop renal papillary necrosis when fed high dose mesalazine for 6 to 12 months.

Beethoven's kidneys had calcareous growths in them, indicating that he was likely developing renal papillary necrosis, a common result of analgesic abuse (it is known that he used large amounts of drugs obtained from his brother Johann, a pharmacist).

A mnemonic for the causes of renal papillary necrosis is POSTCARDS: pyelonephritis, obstruction of the urogenital tract, sickle cell disease, tuberculosis, chronic liver disease, analgesia/alcohol abuse, renal transplant rejection, diabetes mellitus, and systemic vasculitis.