Numerous other enzyme activities have been reported among the 300 known coactivators for nuclear receptors.
As a consequence, nuclear receptors play key roles in both embryonic development and adult homeostasis.
As discussed below, nuclear receptors may be classified according to either mechanism or homology.
There are 270 nuclear receptors in the nematode C. elegans alone.
Humans, mice, and rats have respectively 48, 49, and 47 nuclear receptors each.
The following is a list of the 48 known human nuclear receptors categorized according to sequence homology.
Comparatively little is known about ear-2, but it has been shown to function as a coregulator of other nuclear receptors.
They bind to nuclear receptors in the cell nucleus for genomic actions.
Depending on their mechanism of action and subcellular distribution, nuclear receptors may be classified into at least two classes.
He is particularly interested in nuclear receptors, which are master regulators of metabolism.