receptor down-regulation

ESCRT complexes are central to receptor down-regulation, lysosome biogenesis, and budding of HIV.

Tolerance to drugs is commonly believed to be due to receptor down-regulation (decrease in number), however, there is very limited evidence to support this and comes from animal studies using very high doses.

Tolerance and the resultant withdrawal syndrome may be due to receptor down-regulation and GABA receptor alterations in gene expression which results in long-term changes in the function of the GABAergic neuronal system.

The mechanisms of beta-2 adrenergic receptor down-regulation appear to involve both an increase in the rate of degradation of the receptor as well as a decrease in the levels of beta receptor mRNA [ 7 ] .

We used C6 glioma cells, transfected to stably express the mouse δ-OR, to examine ERK activation by δ-opioids in a line that does not express the EGFR to confirm our results obtained in the receptor down-regulation experiments.

The Emr lab recently identified the ESCRT complexes, which are the first components of a molecular machine required for receptor down-regulation at the endosome (multivesicular body), a late step in cytokinesis, and for the budding and release of HIV.