pyrimidine base

Nucleotides contain either a purine or a pyrimidine base.

Isocytosine or 2-aminouracil is a pyrimidine base that is an isomer of cytosine.

Loss of pyrimidine bases (Cytosine and Thymine) occurs by a similar mechanism, but at a substantially lower rate.

In its composition, deoxythymidine is a nucleoside composed of deoxyribose (a pentose sugar) joined to the pyrimidine base thymine.

The pyrimidine bases cytosine (C) and thymine (T) are smaller and consist of only one aromatic ring.

The formation of pyrimidine dimers upon irradiation with UV light results in an abnormal covalent bond between adjacent pyrimidine bases.

Other than the three major pyrimidine bases presented, some minor pyrimidine bases can also occur in nucleic acids.

For example, UV light can damage DNA by producing thymine dimers, which are cross-links between pyrimidine bases.

The RADD plot will superficially resemble random walks obtained by integrating counts of purine minus pyrimidine bases.

These DNA mutations arise due to chemical changes, the formation of cyclobutane pyrimidine dimers and photoproducts formed between adjacent pyrimidine bases.

In dependence of the bases, parallel DNA could be synthesized for pyrimidine bases in which the chirality of phosphorus was decisive.

Thus, the two substrates of this enzyme are pyrimidine nucleoside and phosphate, whereas its two products are pyrimidine base and alpha-D-ribose 1-phosphate.

UV light can induce adjacent pyrimidine bases in a DNA strand to become covalently joined as a pyrimidine dimer.

A fifth pyrimidine bases, called uracil(U), usually takes the place of thymine in RNA and differs from thymine by lacking a methyl group on its ring.

Halcyon Molecular, in collaboration with the Toste group, proposes that purine and pyrimidine bases can be functionalized with platinum diamine or osmium tetraoxide bipyridine, respectively.

The purine bases (adenine and guanine) and pyrimidine bases (thymidine and cytosine) are bound to deoxyribose and phosphate and incorporated as necessary.

As noted above UVB radiation excites DNA molecules in skin cells, causing aberrant covalent bonds to form between adjacent Pyrimidine bases, producing a dimer.

First, a DNA glycosylase cleaves the N-glycosidic bond, releasing the damaged base and creating an AP site- a site that lacks a purine or pyrimidine base.

Each purine base is the Watson-Crick complement of a unique pyrimidine base (and vice versa) - adenine and thymine form a complementary pair, as do guanine and cytosine.

Model building is a way of bringing into the picture previously determined bond distances and bond angles of components such as the purine and pyrimidine bases and the sugars that are unavailable from the fiber diagram.

For both the purine and pyrimidine bases, the phosphate group forms a bond with the deoxyribose sugar through an ester bond between one of its negatively charged oxygen groups and the 5' -OH of the sugar.

Naturally occurring analogs of purine and pyrimidine bases have been examined extensively for their ability to increase the thermodynamic stability of DNA:DNA and DNA:RNA duplexes [ 11 12 13 14 15 ] .

The mechanism by which UVB induces these cancers is well understood-absorption of UVB radiation causes the pyrimidine bases in the DNA molecule to form dimers, resulting in transcription errors when the DNA replicates.

In biochemistry and molecular genetics, an AP site (apurinic/apyrimidinic site), also known as an abasic site, is a location in DNA that has neither a purine nor a pyrimidine base, either spontaneously or due to DNA damage.

He and his classmates had been given tiny batches of cellular material that belonged to an eel-bird, a denizen of the fifth planet in the Regulus system, and were asked to identify each of the creature's genes by its unique sequence of purine and pyrimidine bases.