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In such conditions as stomach cancer, tumours may partly block the pyloric canal.
The pyloric sphincter, or valve, is a strong ring of smooth muscle at the end of the pyloric canal and lets food pass from the stomach to the duodenum.
Gastric outlet obstruction is the narrowing of pyloric canal by scarring and swelling of gastric antrum and duodenum due to peptic ulcers.
It may temporarily become partially or completely shut off from the remainder of the stomach during digestion by peristaltic contraction of the prepyloric sphincter; it is demarcated, sometimes, from the second part of the pyloric part of the stomach (pyloric canal) by a slight groove.
One long branch of it runs from the lesser curvature or parallel to it in lesser omentum as far as the pyloric antrum to fan out into branches in a way like the digits of a crow's foot to supply the pyloric antrum and the anterior wall of pyloric canal.