purine base

Despite its beer-like flavor, Hoppy contains no purine bases.

Isoguanine or 2-hydroxyladenine is a purine base that is an isomer of guanine.

Most notable among the changes in DNA are the 1,2-intrastrand cross-links with purine bases.

Furosemide inhibits the transport of purine bases through the hFNT1.

Also, folate is needed for purine base synthesis, so all purine synthesis will be inhibited.

Aspartate donates one nitrogen atom in the biosynthesis of inosine, the precursor to the purine bases.

Fpg has a preference for oxidised purines, excising oxidized purine bases such as 7,8-dihydro-8-oxoguanine (8-oxoG).

As a parasitic protazoan, C.luciliae lacks the ability to biosynthetically produce purine bases and therefore needs to salvage them from the surrounding environment.

The purine bases adenine (A) and guanine (G) are larger and consist of two aromatic rings.

Folate is needed to carry one-carbon groups for methylation reactions and nucleic acid synthesis (the most notable one being thymine, but also purine bases).

Purine bases, for instance, react kinetically at N and thermodynamically at N (see Eq.

The structure of this molecule consists of a purine base (adenine) attached to the 1' carbon atom of a pentose sugar (ribose).

Thermal disruption at elevated temperature increases the rate of depurination (loss of purine bases from the DNA backbone) and single-strand breaks.

In DNA, the purine bases are adenine and guanine, while the pyrimidines are thymine and cytosine.

Parasitic protozoa (Leishmania donovani) cannot synthesize purines de novo and utilize the salvage pathway to produce purine bases.

Thus, the two substrates of this enzyme are purine nucleoside and HO, whereas its two products are D-ribose and purine base.

The purine bases (adenine and guanine) and pyrimidine bases (thymidine and cytosine) are bound to deoxyribose and phosphate and incorporated as necessary.

Both RNA and DNA contain two major purine bases, adenine (A) and guanine (G), and two major pyrimidines.

Each purine base is the Watson-Crick complement of a unique pyrimidine base (and vice versa) - adenine and thymine form a complementary pair, as do guanine and cytosine.

Because of the asymmetry in pyrimidine and purine use in coding sequences, the strand with the greater coding content will tend to have the greater number of purine bases (Szybalski's rule).

There he embarked on a study of nucleic acid synthesis with the twin objectives of seeking fundamental knowledge about the roles of pyrimidine and purine bases in growth, and of discovering new chemotherapeutic agents.

The next most important step in research on prebiotic organic synthesis was the demonstration by John Oró that the nucleic acid purine base, adenine, was formed by the simple heating of solutions of ammonium cyanide.

Further, while nucleotides were not found in Miller-Urey's origins of life experiments, their formation in prebiotically plausible conditions has now been reported, as noted above; the purine base known as adenine is merely a pentamer of hydrogen cyanide.

The "dienone" alkylates the purine bases (adenine and guanine) of DNA, and then the alkylated purine parts are spontaneously removed from DNA: subsequently the cleavage of DNA occurs (DNA damage).

In addition, dsDNA (double stranded DNA) in the active site has a wider major groove and shallower minor groove that permits the formation of hydrogen bonds with the third nitrogen of purine bases and the second oxygen of pyrimidine bases.