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Price initially did dental research on the relationship between endodontic therapy and pulpless teeth and broader systemic disease, known as focal infection theory, a theory which resulted in many extractions of tonsils and teeth.
One researcher in 1940 noted "practically every investigation dealing with the pulpless teeth made prior to 1936 is invalid in the light of recent studies" and that the research of Price and others suffered from technical limitations and questionable interpretations of results.