pseudobulbar affect

It is because the condition mimics damage to the brain stem, or bulb, that the company decided to call it pseudobulbar affect.

It is the first FDA-approved drug for the treatment of pseudobulbar affect (PBA).

In 2010, the FDA approved the combination product dextromethorphan/quinidine (Nuedexta) for the treatment of pseudobulbar affect (PBA).

The condition has been variously been known as emotional lability, emotional incontinence, pathological laughing and crying, or uncontrollable laughing and crying, in addition to pseudobulbar affect.

With a grant from Avanir, the National Multiple Sclerosis Society commissioned an article, which is has posted on its Web site, telling doctors how to diagnose pseudobulbar affect.

Historically there have been a variety of terms used, including pseudobulbar affect, pathological laughter and crying, emotional lability, emotionalism, emotional dysregulation, or, more recently, involuntary emotional expression disorder (IEED).

Brain Injury Association of America (BIAA) indicates that approximately 80% of survey respondents experience symptoms of an additional neurologic condition called pseudobulbar affect (PBA).

A combination of dextromethorphan and quinidine, a CYP2D6 inhibitor, has been shown to alleviate symptoms of easy laughing and crying (pseudobulbar affect) in patients with amyotrophic lateral sclerosis and multiple sclerosis.

Pseudobulbar affect is a condition that occurs secondary to neurological disease or brain injury, and is thought to result from disruptions of neural networks that control the generation and regulation of motor output of emotions.

Avanir and its advisers, on the basis of a few papers in the medical literature, came up with an estimate that 880,000 Americans have pseudobulbar affect, which the company rounds to about 1 million in its corporate literature and presentations.

Pseudobulbar affect (PBA), emotional lability, labile affect or emotional incontinence refers to a neurologic disorder characterized by involuntary crying or uncontrollable episodes of crying and/or laughing, or other emotional displays.

Pseudobulbar affect (PBA) is an affective disinhibition syndrome that is largely unrecognized in clinical settings and thus often untreated due to ignorance of the clinical manifestations of the disorder; it may be misdiagnosed as depression.