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In general, this effect is achieved by action on the proximal tubule.
These side effects are due to accumulation of the drug in proximal tubules.
Many types of medications are secreted in the proximal tubule.
This may result in the build up of these drugs in the proximal tubule cells.
The proximal tubule can only reabsorb a limited amount of glucose.
Almost all reabsorption takes place in the proximal tubule.
Glucose at normal plasma levels is completely reabsorbed in the proximal tubule.
This maintains a sodium concentration gradient in the proximal tubule lining, so the first step continues to happen.
Examples include: the liver, the proximal tubules of the kidney, and endocrine glands.
Most of the reabsorption (65%) occurs in the proximal tubule.
Proximal tubule cells can shed with variable viability and not be purely "necrotic".
Na is normally followed by K and Cl out of the proximal tubule.
Affected cells of the proximal tubule may be passed in the urine, but a kidney biopsy is the only sure way to make a diagnosis.
The renal proximal tubule is the primary site of action of osmotic diuretics.
In contrast, creatinine is actually secreted in the proximal tubule.
Amino acids are reabsorbed by sodium dependent transporters in the proximal tubule.
Riboflavin transport by isolated perfused rabbit renal proximal tubules.
The most distinctive characteristic of the proximal tubule is its brush border (or "striated border").
The mitochondria are needed in order to supply the energy for the active transport of sodium ions out of the proximal tubule.
Microvilli can act as mechanosensors in kidney proximal tubule.
In other words, the reabsorption in the proximal tubule is isosmotic.
Once in the kidney, 1,5-AG is re-absorbed back into the blood through the renal proximal tubule.
It is very efficient and can process10-30g of low-molecular-weight proteins per day, so under normal conditions no light chains pass beyond the proximal tubules.
Claudin-2 is expressed in cation-leaky epithelia such as that of the kidney proximal tubule.
Cells, primarily of the straight proximal tubule, swell due to the formation of large vacuoles in the cytoplasm.