proto-oncogene

These data suggests that Shp2 may be a proto-oncogene.

EVI1 has been described as a proto-oncogene since its first discovery in 1988.

This proto-oncogene may play a role in the regulation of embryonic development and cell growth.

CD135 is a proto-oncogene, meaning that mutations of this protein can lead to cancer.

The proto-oncogene can become an oncogene by a relatively small modification of its original function.

They identified a new mouse proto-oncogene that they named int1 (integration 1).

When Wnt1 was discovered, it was first identified as a proto-oncogene in a mouse model for breast cancer.

His discovery provided a role for members of the proto-oncogene pp60src kinase family in normal cell signaling.

Proapoptotic function of p53 appears to be regulated by ras proto-oncogene.

FOXM1 gene is now known as a human proto-oncogene.

Plk1 is considered a proto-oncogene, whose overexpression is often observed in tumor cells.

A proto-oncogene is a normal gene that can become an oncogene due to mutations or increased expression.

These transactivators can also be associated with cancer if they start interacting and increasing expression of a cellular proto-oncogene.

Mutations in the K-ras proto-oncogene are responsible for 10-30% of lung adenocarcinomas.

Raf is a proto-oncogene because mutations in this protein have been found in many cancers.

A proto-oncogene is a gene that can cause cancer if it is mutated or over-expressed.

Upon activation, a proto-oncogene (or its product) becomes a tumor-inducing agent, an oncogene.

Pim-1 is a proto-oncogene which encodes for the serine/threonine kinase of the same name.

The virus causes overexpression of that proto-oncogene, which typically induces uncontrolled cell division.

Transformation of proto-oncogene to oncogene is the result of gain in function through:

HRAS has been shown to be a proto-oncogene.

The RET proto-oncogene on chromosome 10 was identified as one of the two genes involved.

Indeed, one proto-oncogene identified in the tissues of an early embryo appears to play a part in the natural development of the central nervous system.

The oncovirus can switch this pre-existing benign proto-oncogene on, turning it into a true oncogene that causes cancer.

The mammalian c-myc gene is a proto-oncogene which is required for cell proliferation, transformation and death.