prothrombinase

Factor X is part of fresh frozen plasma and the prothrombinase complex.

Assembly of the prothrombinase complex is calcium dependent.

Deficiencies of either protein components of the prothrombinase complex are very rare.

Further, membrane-bound Factor Va provides a strong catalytic advantage to the prothrombinase complex.

Thus, the prothrombinase complex is required for the efficient production of activated thrombin and also for adequate hemostasis.

Thus, the formation of the prothrombinase complex alters the sequence of prothrombin bond cleavage.

When associated with the prothrombinase complex, the catalytic efficiency of Factor Xa is increased 300,000-fold compared to its efficiency alone.

The digestive vacuole membrane has the capacity to assemble prothrombinase, a key enzyme of the intrinsic clotting pathway.

Factor Xa is the prime component of the prothrombinase complex which converts large amounts of prothrombin-the "thrombin burst".

This process is optimized when factor Xa is complexed with activated co-factor V in the prothrombinase complex.

The prothrombinase complex can catalyze the activation of prothrombin at a rate 3 x 10-fold faster than can Factor Xa alone.

Factor Va also decreases the Km of the reaction by enhancing the binding of prothrombin to the prothrombinase complex.

The fully assembled prothrombinase complex catalyzes the conversion of the zymogen prothrombin to the serine protease thrombin.

Several enzyme complexes of blood coagulation cascade such as tenase and prothrombinase are activated by the cell surface exposure of the phosphatidylserine.

FXa and its co-factor FVa form the prothrombinase complex, which activates prothrombin to thrombin.

PS-exposing MP in blood appear to act as the catalytic surface for assembly of the prothrombinase complex [ 7 ] .

This "tenase" complex activates more Factor X, which in turn forms new prothrombinase complexes with Factor Va.

The prothrombinase complex consists of the serine protease, Factor Xa, and the protein cofactor, Factor Va.

To produce thrombin, the prothrombinase complex cleaves two peptide bonds in prothrombin, one after Arg and the other after Arg.

The activity of factor Xa is greatly enhanced by binding to activated Factor V (Va), termed the prothrombinase complex.

Once bound to the plasma membrane, Factor Xa and Factor Va rapidly associate in a 1:1 stoichiometric ratio to form the prothrombinase complex.

Rivaroxaban is an oxazolidinone derivative optimized for inhibiting both free Factor Xa and Factor Xa bound in the prothrombinase complex.

Although it has been shown that Factor Xa can activate prothrombin when unassociated with the prothrombinase complex, the rate of thrombin formation is severely decreased under such circumstances.

Thrombin is produced from prothrombin, by the action of an enzyme, prothrombinase (Factor Xa along with Factor Va as a cofactor), in the final states of coagulation.

Membrane bound fgl2 (mfgl2) exhibits a prothrombinase activity, resulting in fibrin deposition, vascular thrombosis and tissue inflammation within an affected tissue, largely contributing to the innate arm of immunity.