Argyria following the use of dietary supplements containing colloidal silver protein.

Colloidal silver proteins marketed as health supplements.

When compounded into varying strengths, nevertheless Argyrol is silver protein identified as to its molecular construct.

Argyrol is the trade name for an antiseptic consisting of compounded solutions at varying strengths of mild silver protein.

Designer of first silver protein formulation was Arthur Eichengrün, German chemist working for Bayer.

Although Argyrol is used as a synonym in chemical description also as silver vitellin and mild silver protein, Barnes insisted to differentiate Argyrol was not the same.

Thereafter, Argyrol Anti-Infective became infrequently prescribed because Argyrol 10% Stabilized Solution was available over-the-counter in pharmaceutical distribution, while prescription permitted compounding pharmacists to provide designer solutions of mild silver protein.

The silver protein molecule is Argyrol in use for over 100 years to date, ample in clinical data support of the benefits and versatility of the silver protein molecule in medicine without detriment of drug resistance.

Agyrol is synonymous with its chemical mild silver protein, manufactured in the chemical industry to pharmaceutical grade only, using denatured pharmaceutical grade protein for opthalamic application and elemental silver to produce the silver protein molecule.

Argyrol was never patented because Barnes strategized perpetuation of Argyrol exclusivity in perpetuity through his trademark description of Argyrol as the molecule silver protein in its chemical description, namely colloidal silver protein for antiseptic use to mucous membranes.

Silver nitrate was one of the widely used drugs in the 19th century, but it became replaced by Protargol.

Protargol stayed in use until sulfa drugs and then antibiotics became available in the 1940s.

In 1897, Protargol, a silver salt of a protein mixture, developed by Eichengrün at Bayer, was introduced as a new drug against gonorrhea.

Silver proteinate (brand name: Protargol) is used in electron microscopy with periodic acid and thiocarbohydrazide or thiosemicarbohydrazide as a positive stain for carbohydrates such as glycogen.