protamine sulfate

Protamine sulfate will reverse Tinzaparin by 85% per package insert.

Protamine sulfate is an antidote for heparin overdose.

Protamine sulfate is a drug that reverses the anticoagulant effects of heparin by binding to it.

Protamine sulfate is usually administered to reverse the large dose of heparin administered during certain surgeries, especially heart surgery.

FLS were cultured with viral supernatant plus protamine sulfate (5 μg/ml) for 24 hours.

Heparin is the most commonly used anticoagulant in hemodialysis, as it is generally well tolerated and can be quickly reversed with protamine sulfate.

The patient is administered heparin to prevent clotting, and protamine sulfate is given after to reverse effects of heparin.

The anticoagulant effects of heparin are typically reversible with protamine sulfate, while protamine's effect on LMWH is limited.

Dosage for heparin reversal is 1 mg protamine sulfate i.v. for every 100 IU of active heparin.

The following day, the medium was replaced with 2 ml of fresh medium containing a defined volume of viral supernatant, supplemented with protamine sulfate (5 μg/ml).

In gene therapy, protamine sulfate has been studied as a means to increase transduction rates by both viral and nonviral (e.g. utilizing cationic lipids) mediated delivery mechanisms.

Protamine sulfate (1 mg per 100 units of heparin that had been given over the past four hours) has been given to counteract the anticoagulant effect of heparin.

A disadvantage recognised early was the absence of an antidote in case acute bleeding develops, while warfarin can be antagonised by vitamin K and heparin by protamine sulfate.

Retroviral supernatant was collected 48 hours after transfection, filtered through a 0.45 μM filter (Nalgene, Rochester, NY, USA), supplemented with 5 μg/ml protamine sulfate (Elkins-Sinn, Inc.

In gene therapy, protamine sulfate's ability to condense plasmid DNA along with its approval by the U.S. Food and Drug Administration (FDA) have made it an appealing candidate to increase transduction rates by both viral and nonviral (e.g. utilizing cationic liposomes) mediated delivery mechanisms.