prolactin receptor

There may be variation among different tissue prolactin receptors.

JAK2 signaling is activated downstream from the prolactin receptor.

Human prolactin receptors are insensitive to mouse prolactin.

When prolactin binds to the receptor, it causes it to dimerize with another prolactin receptor.

Development is caused by activation of estrogen receptor alpha, progesterone receptors, and prolactin receptors contained in mammary cells.

The activation of the prolactin receptor also results in the activation of mitogen-activated protein kinases and Src kinase.

Prolactin acts in endocrine, autocrine, and paracrine manner through the prolactin receptor and a large number of cytokine receptors.

Antibodies/antagonists for other hormones/receptors such as androgen receptors and prolactin receptors, which are present in a high proportion of breast cancers.

Cells with none of these receptors are called triple-negative although they frequently express receptors for other hormones such as androgen receptor and prolactin receptor.

The antitumor activity of fluoxymesterone appears related to reduction or competitive inhibition of prolactin receptors or estrogen receptors or production.

Their binding ensures correct placement of prolactin receptors on the basal lateral side of alveoli cells and directional secretion of milk into lactiferous ducts.

Placental lactogen I and II were identified as prolactin-like molecules that can bind to prolactin receptor with high affinity and mimic the actions of prolactin.

(see Estrogen, Prolactin, Prolactin receptor, OCP, Hormonal Implants, Endocrinology, Pregnancy).

PRL (Prolactin), PRLR (Prolactin receptor) implicated in ASD.

One additional point is that signaling pathways activated by the EpoR are common to many other receptors; replacing EpoR with prolactin receptor supports erythroid survival and differentiation in vitro.

Prolactin receptors are present in the mamillary glands, ovaries, pituitary glands, heart, lung, thymus, spleen, liver, pancreas, kidney, adrenal gland, uterus, skeletal muscle, skin, and areas of the central nervous system.

The exact mechanism by which it inhibits GnRH is poorly understood although expression of prolactin receptors (PRL-R) have been demonstrated in rat's hypothalmus,the same has not been observed in GnRH neurons.