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It has selective progestogenic properties without any traditional hormonal activity.
Pincus asked his contacts at pharmaceutical companies to send him chemical compounds with progestogenic activity.
The oral progestogenic potency of dydrogesterone is 20 times higher than that of progesterone.
Spironolactone has weak progestogenic properties.
Although commonly compared to nandrolone, boldenone lacks progesterone receptor interaction and all the associated progestogenic side effects.
Progestins, synthetic substances with progestogenic activity are used in birth control pills, implants and the intrauterine system IUS (Mirena).
It has pronounced progestogenic effects and opposes the proliferative effects of estrogen in the utereus, but lacks anabolic, androgenic, estrogenic and corticoid activity.
Experience from experimental aromatase inhibitor treatment of endometriosis indicates that aromatase inhibitors might be particularly useful in combination with a progestogenic ovulation inhibitor.
Spironolactone's progestogenic actions are thought to be responsible for some of its side effects, including the menstrual irregularities seen in women and the undesirable serum lipid profile changes (which are both seen with other progestins as well) that are seen at higher doses.
Findings on a relatively new form of HRT called tibolone- a synthetic steroid with estrogenic, androgenic, and progestogenic properties- suggest that it has the ability to improve mood, libido, and somatic symptoms of surgically menopausal women to a greater degree than ERT.