primary hypogonadism

Hypogonadism resulting from defects of the gonads is traditionally referred to as primary hypogonadism.

Aromatase inhibitors have been shown to reverse age-related declines in testosterone, including primary hypogonadism.

A karyotype can confirm or exclude forms of dysgenetic primary hypogonadism, such as Klinefelter syndrome or mixed gonadal dysgenesis.

It may occur because of testicular dysfunction (primary hypogonadism) or hypothalamic-pituitary dysfunction (secondary hypogonadism) and may be congenital or acquired.

In primary hypogonadism the LH and/or FSH are usually elevated, meaning the problem is in the testicles, whereas in secondary hypogonadism, both are normal or low, suggesting the problem is in the brain.