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During preantral follicle growth, expression increased reaching high maximal levels in the GC of secondary follicles (Fig.
In the early stages of primary follicle development the levels of BMPR-IA mRNA in the oocyte increased and were maximal in late preantral follicles (Fig.
In the preantral follicles, only the membrana GC expressed BMP-6 mRNA, consistent with a role of the oocyte in regulating GC BMP-6 expression (Fig.
In preantral follicles, BMP-2 mRNA expression was confined mainly to the membrana GC with little or no expression in the corona radiata GC next to the oocyte (Fig.
The formation of a fluid-filled cavity adjacent to the oocyte called the antrum designates the follicle as an antral follicle, in contrast to so a called preantral follicle that still lacks an antrum.