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"That's why it appears that there is a very substantial loss of life."

"We'll have to figure out how we can survive with a substantial loss of revenues."

"They will have to take a choice between taking a substantial loss immediately or having their money tied up for several years."

The company said the charges would result in a substantial loss for 1989.

Whatever the reason, this business made a very substantial loss.

How can taking away major domain names for a web based company not be a substantial loss?

"The fact that we had no substantial loss of life was a miracle," he said.

On Thursday the company said it would have a substantial loss in the current quarter.

It was closed down on March 31, 1998 after substantial losses.

The German company eventually 'walked away' with further substantial losses.

A number of books were published at a heavy loss.

A heavy loss had been made upon the construction of R.100.

Some thought was given to selling the land at a heavy loss.

Such a move could mean a third year of heavy losses for the company.

The war continued with heavy loss of life on both sides for two years.

The heavy loss of life was seen as a blow to the military.

Why should we pay for something that means heavy losses?

It was their first heavy loss in two months of combat.

But we'd take heavy losses, and they'd break through in the end.

That I will sustain a heavy loss, under your decision, is beyond question.

He will be a serious loss to his family.

All this would amount to a serious financial loss for the company.

By doing this the house would risk having to write off its already very serious losses.

The dead on the floor told him that his own men had suffered serious losses.

The problem with the move is that it could result in a serious loss of income for the company.

But the distances are so great there would be no serious loss of life.

Right after a serious loss or difficult life change (the death of someone close, a stressful move).

It suffered a serious loss of foreign investment as a result.

My death, let me tell you, would mean a serious financial loss to her.

If they both go, it is a very serious loss at the top of our foreign service.

In old age several major losses may occur within a short space of time.

The major loss seemed to be one of the men.

"And we still use these, for patients with major loss."

"His death represents a major loss for the medical community."

Had several major losses in a short period of time.

They'd feel a sense of major loss if they had to throw this stuff away.

For a man who was a star in Japan, this could be a major loss of face.

This process has caused a major loss of land on the island.

Not that he could fault himself for his one major loss.

Older adults often have many major losses within a short period of time.