postsynaptic depolarization

There are two necessary components of LTP: presynaptic glutamate release and postsynaptic depolarization.

NMDARs are known to be coincidence detectors of presynaptic activity and postsynaptic depolarization.

When one pathway into a synapse is stimulated weakly, it produces insufficient postsynaptic depolarization to induce LTP.

LTD is induced by a minimum level of postsynaptic depolarization and simultaneous increase in the intracellular calcium concentration at the postsynaptic neuron.

This gives the NMDAR the property of being voltage-dependent, in that it requires strong postsynaptic depolarization to allow ion flux.

The postsynaptic depolarization will subside by the time an EPSP occurs, enabling Mg to return to its inhibitory binding site.

Vincent P, Armstrong CM, Marty A. (1992) Inhibitory synaptic currents in rat cerebellar Purkinje cells: modulation by postsynaptic depolarization.

Borrowing its name from Hebb's postulate, summarized by the maxim that "cells that fire together wire together," Hebbian LTP requires simultaneous pre- and postsynaptic depolarization for its induction.

The mechanism of the first is similar to CA1-LTD: a low frequency stimulus induces LTD by activation of NMDA receptors, with postsynaptic depolarization and increased postsynaptic calcium influx.

The synaptic changes depend on a special type of glutamate receptor, the NMDA receptor, which has the special property of allowing calcium to enter the postsynaptic spine only when presynaptic activation and postsynaptic depolarization occur at the same time.