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We found no statistically significant rise in G34 postprandially, either in the presence or absence of H pylori.
Chromatographic analysis was performed on serum samples obtained 20 minutes postprandially before and after eradication of H pylori in six patients.
PYY concentration in the circulation increases postprandially (after food ingestion) and decreases by fasting.
Again there was no significant difference between the morbidly obese and normal group's urinary APGPR excretion at any given time postprandially.
Different forms of circulating gastrin were studied both basally and postprandially in 13 duodenal ulcer patients before and one month after eradication of H pylori.
Indeed, previous in vivo studies have shown that intravenous administration of PYY in man at plasma concentrations seem postprandially inhibits gastric emptying and intestinal transit.
Successful therapy is measured by a loss of glycosuria, blood glucose levels less than 10.0 mmol/l postprandially and a glycosylated haemoglobin of 10.0 per cent or less.
While some studies have shown obese persons have lower circulating level of PYY postprandially, other studies have reported they have normal sensitivity to the anorectic effect of PYY.
The significant difference at 45 and 360 minutes postprandially between the results in the normal and these two morbidly obese subjects cannot be accounted for by a difference in the urine output (one way ANOVA, p>0.05).
A similar difference in urinary APGPR excretion postprandially was seen between the normal subjects and MO1 and MO3 and was significant at 15, 30, and 45 minutes after the start of the meal (data not shown).
This study was performed in an attempt to identify APGPR in blood after a satiating meal and to investigate the hypothesis that APGPR is absorbed into the circulation postprandially and may appear in urine.
In the normal subjects the fasted mean serum APGPR concentration was at the detection limit of the assay but postprandially two peaks of APGPR immunoreactivity were seen in the first and second hours after the start of the meal (Fig 1).