polyoma

There he started his studies about animal oncoviruses, especially of polyoma family.

They next turned their attention to cancer causing viruses, beginning with the polyoma virus.

In human breast cancer the polyoma middle T- antigen was not found.

This virus appears to be related to the human and other primate polyoma viruses.

A polyoma virus has been isolated from horses.

The polyoma virus affects tyrosine kinase activity inside the nuclear matrix.

The polyoma middle T-antigen is taken from the polyoma virus.

The name polyoma refers to the viruses' ability to produce multiple (poly-) tumors (-oma).

In 2012 another polyoma virus - MX polyomavirus - was isolated from stool samples.

The virus was later named the SE Polyoma Virus in their honor.

Cytochalasin B is unable to transform 3T3-like tumor cells, but it did increase the frequency of cell transformation by the polyoma virus 8-40 fold.

In addition it may potentially increase the severity of existing fungal or infectious conditions such as herpes zoster or polyoma viral infections.

When these cells are transformed by the polyoma virus, higher tyrosine activity is observed in the cellular matrix, which is also correlated to cellular proliferation.

One group is the establishing genes such as myc,Ela and the other is the transforming genes including ras and polyoma middle T genes.

It is caused by primary infection or reactivation of Jamestown Canyon virus (JCV), a ubiquitous polyoma virus.

Dr. Sarah Stewart and Dr. Bernice E. Eddy were the first to describe the polyoma virus.

The structural proteisn resemble those of the pappiloma viruses while the T and t antigens resemble those of the polyoma viruses.

In 2012 a new polyoma virus (Malawi polyomavirus - MWPyV) was isolated from the stool of a healthy child from Malawi.

In 2012 another new polyoma virus - human polyoma virus 10 - has been isolated from patient with the warts, hypogammaglobulinemia, infections and myelokathexis syndrome.

He carried out his PhD studies with Lionel Crawford in London working on chromatin organisation and DNA sequence specificity using polyoma virus.

Two further polyoma viruses have been isolated from humans - STL polyomavirus and MW polyoma virus.

In March, 2011, a ninth polyoma virus HPyV9, related to a monkey lymphotropic virus (LPV) was cultured from the blood of immunosuppressed patients.

The discovery of PI 3-kinases by Lewis Cantley and colleagues began with their identification of a previously unknown phosphoinositide kinase associated with the polyoma middle T protein.

Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation.

Eckhart, W., Hutchinson, M.A., and Hunter, T. (1979) An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates.